Serotonin Transporter
5-HTT; SERT; SLC6A4
Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.
Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.
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Serotonin Transporter Inhibitors
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Serotonin Transporter Agonists
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Serotonin Transporter Antagonists
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Serotonin Transporter Activators
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Serotonin Transporter Modulators
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Serotonin Transporter Controls
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Serotonin Transporter Substrates
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Serotonin Transporter Ligands
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Serotonin Transporter Related Products (310)
Related Products (310)
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Antibodies (3)
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Antidepressant agent 9
0 ImagesCat. No.: HY-170945CAS No.: 143899-90-5Antidepressant agent 9 (Compound 24) is an orally active and BBB-penetrable NMDAR and SERT inhibitor with IC50 values of 3.50 μM and 1044 nM, respectively. Antidepressant agent 9 has good metabolic stability and plasma exposure. Antidepressant agent 9 can exert antidepressant-like activity in the mouse forced swim test.
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Dapoxetine-d6
0 ImagesCat. No.: HY-B0304SCAS No.: 1132642-58-0Dapoxetine-d6 is the deuterium labeled Dapoxetine. Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE).
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Imipramine-d4
0 ImagesCat. No.: HY-B1490AS1CAS No.: 96705-18-9Imipramine-d4 is deuterium labeled Imipramine. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects.
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(Rac)-Atomoxetine hydrochloride
0 ImagesCat. No.: HY-107370ACAS No.: 82857-40-7Synonyms: (Rac)-Tomoxetine hydrochloride; (Rac)-LY 139603(Rac)-Atomoxetine hydrochloride ((Rac)-Tomoxetine (hydrochloride); (Rac)-LY 139603) is the racemic mixture of Atomoxetine hydrochloride (HY-17385). Atomoxetine hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research.
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Wf-516 hydrochloride
0 ImagesCat. No.: HY-19417CAS No.: 310392-93-9Wf-516 hydrochloride is an inhibitor of 5-HT reuptake, and an antagonist of 5-HT1A and 5-HT2A receptors, with Ki of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively.Wf-516 hydrochloride has potent antidepressant activity.
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5-HT1AR agonist 2
0 ImagesCat. No.: HY-1693945-HT1AR agonist 2 (Compound 4f) is a 5-HT1A receptor agonist (Ki: 10.0 nM). 5-HT1AR agonist 2 also binds to the SERT, D2 receptor and 5-HT6 receptor (Ki: SERT, 2.8 nM; D2, 23 nM; 5-HT6, 192 nM). 5-HT1AR agonist 2 is stabilized in microsomes and induces hypothermia in mice.
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Levomilnacipran-d10 hydrochloride
0 ImagesCat. No.: HY-14794ASCAS No.: 2747914-23-2Synonyms: (1S,2R)-Milnacipran-d10 hydrochloride; F2695-d10 hydrochlorideLevomilnacipran-d10 ((1S,2R)-Milnacipran-d10) hydrochloride is deuterium labeled Levomilnacipran hydrochloride (HY-B0168B). Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC50 values of 10.5 nM and 19.0 nM, and Ki values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression.
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Oxaflozane
0 ImagesCat. No.: HY-105774CAS No.: 26629-87-8Oxaflozane is a non-tricyclic antidepressant with serotoninergic action. Oxaflozane has anti-cataleptic and anti-aggressive actions with a weak potentiation of the stereotypes provoked by Amphetamin.
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Norquetiapine dihydrochloride
0 ImagesSynonyms: N-Desalkylquetiapine dihydrochlorideNorquetiapine ( N-Desalkylauetiapine) dihydrochloride, a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC50 of 13.9 μM. Norquetiapine dihydrochloride selectively inhibits noradrenaline reuptake, is a partial 5-HT1A (Ki = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (Ki = 237 nM), 5-HT2C(Ki = 107 nM), and 5-HT7 (Ki = 76 nM) receptors. Norquetiapine dihydrochloride blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine dihydrochloride shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine dihydrochloride can be used for the study of depression and inflammation.
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Clomipramine-d3
0 ImagesCat. No.: HY-B0457ASCAS No.: 136765-29-2Synonyms: Chlorimipramine-d3; G-34586-d3; NSC-169865-d3Clomipramine-d3 is the deuterium labeled Clomipramine. Clomipramine is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.
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Citalopram oxalate
0 ImagesCat. No.: HY-121203ACAS No.: 207559-01-1Citalopram oxalate is a serotonin uptake inhibitor that serves as an antidepressant, effectively reducing ethanol uptake in alcoholics and offering a preferable option for depressed patients experiencing tardive dyskinesia compared to tricyclic antidepressants, which may worsen this condition.
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Vilazodone-d8 hydrochloride
0 ImagesCat. No.: HY-14262S1Synonyms: EMD 68843-d8; SB659746A-d8Vilazodone-d8 hydrochloride is deuterated labeled Vilazodone (HY-14262). Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT1A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders.
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Vortioxetine-d8
0 ImagesCat. No.: HY-15414SCAS No.: 2140316-62-5Synonyms: Lu AA 21004 d8Vortioxetine-d8 (Lu AA 21004-d8) is a deuterated version of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT3A and 5-HT7 receptors (Ki: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (Ki: 1.6 nM), as well as a 5-HT1A agonist and a partial 5-HT1B agonist (Ki: 15 nM, 33 nM).
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Paroxetine hydrochloride (Standard)
0 ImagesSynonyms: BRL29060 hydrochloride (Standard); BRL29060A (Standard)Paroxetine (hydrochloride) (Standard) is the analytical standard of Paroxetine (hydrochloride). This product is intended for research and analytical applications. Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an GRK2 inhibitor with IC50 of 14?μM. Paroxetine hydrochloride can be used for the research of depressive disorder.
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Paroxetine hydrochloride hemihydrate (Standard)
0 ImagesSynonyms: BRL29060 hydrochloride hemihydrate (Standard); BRL29060A hemihydrate (Standard)Paroxetine (hydrochloride hemihydrate) (Standard) is the analytical standard of Paroxetine (hydrochloride hemihydrate). This product is intended for research and analytical applications. Paroxetine hydrochloride hemihydrate is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14?μM.
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Alaproclate hydrochloride
0 ImagesCat. No.: HY-133732CAS No.: 60719-83-7Synonyms: GEA 654 hydrochloride; A03 hydrochlorideAlaproclate (GEA 654) hydrochloride is a selective and orally active serotonin re-uptake inhibitor (SSRI). Alaproclate hydrochloride also acts as a potent, reversible and noncompetitive antagonist of the NMDA receptor coupled ion flow.
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Vortioxetine-d3
0 ImagesCat. No.: HY-15414S3CAS No.: 1629684-22-5Synonyms: Lu AA 21004-d3Vortioxetine-d3 (Lu AA 21004-d3) is a deuterium labeled Vortioxetine (HY-15414). Vortioxetine (Lu AA 21004) is an antagonist of 5-HT3A and 5-HT7 receptors (Ki: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (Ki: 1.6 nM), as well as a 5-HT1A agonist and a partial agonist of 5-HT1B (Ki: 15 nM, 33 nM).
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nNOS-PDZ-IN-1
0 ImagesCat. No.: HY-184410nNOS-PDZ-IN-1 is an orally active, blood-brain barrier-penetrant inhibitor of neuronal nitric oxide synthase-PDZ domain (nNOS-PDZ), with an IC50 of 0.76 μM and a KD of 0.55 μM. nNOS-PDZ-IN-1 binds to the nNOS-PDZ domain, occupies its binding site and disrupts its interaction with the serotonin transporter. nNOS-PDZ-IN-1 exhibits antidepressant activity without addiction potential or movement-related side effects. nNOS-PDZ-IN-1 can be used in research related to major depressive disorder.
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Citalopram (Standard)
0 ImagesCitalopram (Standard) is the analytical standard of Citalopram. This product is intended for research and analytical applications. Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active selective serotonin reuptake inhibitor (SSRI). Citalopram is an antidepressant and enhances serotoninergic neurotransmission.
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Dapoxetine-d7
0 ImagesCat. No.: HY-170021CAS No.: 1132642-56-8Synonyms: LY-210448-d7Dapoxetine-d7 (LY-210448-d7) is the deuterium labeled Dapoxetine (HY-B0304). Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE).
